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Abstract Information
This program offers 16.5 hours of Continuing Veterinary Medical Education for veterinarians.
| Monday, May 24 | |
| 08:00 | Registration |
| 09:00 | Welcome & Introduction |
| 09:10 | Session I: Viral Genomics and Evolution Keynote Address: Pathogenicity, transmission patterns and population impact of SIVcpz infection in its natural chimpanzee host Beatrice Hahn |
| 10:00 | Break |
| 10:30 | Virus evolutionary genomics: The agony and (sometimes) crazy ecstasy Mary Poss |
| 11:00 | Alterations of neutralization and receptor binding properties are mediated by mutations in the V5 loop of FIV Martin Kraase |
| 11:30 | FIV evolution in wild lions: Insights from the Env gene Jill Pecon-Slattery |
| 12:00 | Lunch |
| 13:30 | Session II: FIV/FeLV: Virus and Vector Generation of restriction factor-transgenic domestic cats Eric Poeschla |
| 14:00 | The frequency of occurence and nature of recombinant FeLVs in the induction of multicentric lymphoma by infection of the domestic cat with FeLV-945 Shamim Ahmad |
| 14:15 | Enhanced binding of the surface glycoprotein of FeLV-945 from a natural cohort may alter the disease spectrum Lisa Bolin |
| 14:30 | Rapid development of lymphomas in cats with virulent FIV infection Martha MacMillan |
| 14:45 | FeLV inhibition in vitro by peptides derived from the transmembrane protein Eva Boenzli |
| 15:00 | Break |
| 15:30 | Session III: Intracellular Restriction to Retroviral Infection Retroviral restriction in the feliformia: A role for TRIM5α? Brian Willett |
| 15:50 | Restriction of FeLV in murine and human cells expressing the FeLV-A receptor Shamim Ahmad |
| 16:10 | Cat tetherin is a potent retorviral restriction factor Isabelle Dietrich |
| 16:30 | The reduction of P27 FELV protein expression in feline cells by interference RNA Sócrates Ornelas |
| 16:50 | FIV tissue distribution during co-infection with avirulent lentivirus Sue VandeWoude |
| 17:30 | Bus departs Mills House for Middleton Place |
| 18:00 | Conference Dinner at Middleton Place |
| Tuesday, May 25 | |
| 09:00 | Session IV: Clinical Aspects of FIV/FeLV Clinical aspects of feline immunodeficiency and FeLV infection Katrin Hartmann |
| 09:30 | Seroprevalence of FeLV and FIV infection in Canada Susan Little |
| 09:45 | Incidence of progressive and regressive FeLV infection in cats with lymphoma Bianca Stuetzer |
| 10:00 | Hematalogical alterations in cats infected with FIV or FeLV Esperanza Gomez-Lucia |
| 10:15 | Break |
| 10:45 | Steroid deregulation in cats infected with FIV and/or FeLV Esperanza Gomez-Lucia |
| 11:00 | Effect of a Neruokinin-1 receptor antagonist (aprepitant) on FIV viral load in seropositive cats Angela Mexas |
| 11:15 | Comparison of different therapies in cats spontaneously injected with FIV: Zidovudine versus zidovudine associated to valproic acid Nelida Virginia Gomez |
| 11:30 | Evolution of the CD4:CD8 ratio and virological parameters in FIV or FeLV infected cats treated with recombinant human interferon-alpha Esperanza Gomez-Lucia |
| 11:45 | Lunch and poster viewing |
| 13:15 | Session V: Vaccines A customized boost of engineered T-lymphocytes induces high level neutralizing antibody and affords marked protection against FIV Mauro Pistello |
| 13:45 | Development of Lactobillus gasseri as a vaccine vector against FIV/HIV Laura Stoeker |
| 14:05 | Cross-reactive FIV epitopes in the development of an HIV-1 vaccine for humans Patrick Sanou |
| 14:25 | Establishing a model of lentiviral cellular latency in the FIV-C infected cat Brian Murphy |
| 14:45 | Break |
| 15:15 | Session VI: Neuropathogenesis The entry of immunodificiency-inducing lentiviruses into the central nervous system: Barriers to overcome Sean Callanan |
| 15:45 | Novel neuroprotective strategies for FIV Rick Meeker |
| 16:15 | Early cognitive decline following intracerebroventricular FIV inoculation G Clary |
| 16:35 | Strain-specific neuropathology of FIV Craig Miller |
| 19:00 | Steering committee dinner/meeting Open evening for attendees |
| Wednesday, May 26 | |
| 08:30 | Session VII: Feline Genomics and Application of Genomic Tools Title TBD Steve O'Brien |
| 09:00 | Analysis of virus-host interactions in FIV-infected cells using massive parallel sequencing technology Dieter Klein |
| 09:20 | Looking for footprints of viral selection on the feline and canine transferrin receptor sequence Colin Parrish |
| 09:40 | Break |
| 10:10 | Session VIII: Immunopathogenesis: Regulatory T-Cells Introduction to regulatory T-cells Dorothee Bienzle |
| 10:25 | FIV infection induces immune deficiency of CD4+Th and CD8+ T-cells via upregulation of mTGFB on T-reg cells and TGBRII on target T-cells |
| 10:45 | A unique cell cycle profile in CD8+ lymphocytes from FIV+ cats following CD4+CD25+ T-regulatory cell co-culture may help explain impaired CD8+ responses during AIDS lentiviral infections Jonathan Fogle |
| 11:05 | FoxP3 inhibits NFAT2-dependent IL-2 production and causes anergy in CD4+CD25+ T regulatory cells in chronic FIV infection Liping Meng |
| 11:25 | Regulatory T-cell depletion prior to FIV infection does not alter acute disease pathogenesis Rochelle Mikkelsen |
| 11:45 | Lunch |
| 13:15 | Session IX: Immunopathogenesis: Innate Immunity Introduction to innate immunity Paul Avery |
| 13:30 | FIV as a model for studies of innate immune cell function during lentiviral infections Wendy Sprague |
| 13:50 | In vivo assessment of natural killer cell functional impairment during chronic feline immunodeficiency virus infection Rita Simoes |
| 14:10 | Induction of resistance to viral infections in the cat by stimulation of the innate immune system Celine Robert |
| 14:30 | Development, optimization and validation of a multiplex microsphere-based feline cytokine assay Britta Wood |
| 14:50 | Break |
| 15:20 | Session X: Non-Domestic Cats and Epidemiology Genetic determinants of pathogenesis by feline infectious peritonitis virus (FIPV): A study of free-ranging cat isolates Meredith Brown |
| 15:40 | Use of host and pathogen molecular markers to determine population substructure among bobcats (Lynx rufus) in a fragmented landscape in southern California Justin Lee |
| 16:00 | Detection of feline foamy virus-specific antibodies in domestic and wild cats Martin Loechelt |
| 16:20 | Evolutionary dynamics of endogenous feline leukemia virus proliferation among species of the domestic cat lineage Alfred Roca |
| 16:40 | Development of a product enhanced reverse transcriptase (pert) assay to determine retorvirus viral load in the plasma of wild African lions Melody Roelke |
| 19:00 | Reception at aquarium, young investigator awards and farewell |
Posters
Quantification and molecular characterization of the FeLV A receptor
Katrin Helfer-Hungerbuehler
Are endogenous FeLVs really endogenous?
Hazel Stewart
Concentration and purification of FIV using tangential flow filtration and ultra centrifugation
Melanie Ammerbach
Expression of programmed cell death molecules on feline CD4+ cells
Andrea Achleitner
Investigation of the relationship between cell signalling and the growth and latency of FIV
Chi Ngai Chan
The use of recombinant interferon-omega in naturally FeLV, FIV or co-infected cats: a case report
Esperanza Gomez-Lucia
Evaluation of adrenal and thyroid axes in natural FIV-infected cats, with and without antiviral treatment
Nelida Virginia Gomez
