This program offers 16.5 hours of Continuing Veterinary Medical Education for veterinarians.
| Monday, May 24 |
| 08:00 |
Registration |
| 09:00 |
Welcome & Introduction |
| 09:10 |
Session I: Viral Genomics and Evolution
Keynote Address: Pathogenicity, transmission patterns and population impact of SIVcpz infection in its natural chimpanzee host
Beatrice Hahn |
| 10:00 |
Break |
| 10:30 |
Virus evolutionary genomics: The agony and (sometimes) crazy ecstasy
Mary Poss |
| 11:00 |
Alterations of neutralization and receptor binding properties are mediated by mutations in the V5 loop of FIV
Martin Kraase |
| 11:30 |
FIV evolution in wild lions: Insights from the Env gene
Jill Pecon-Slattery |
| 12:00 |
Lunch |
| 13:30 |
Session II: FIV/FeLV: Virus and Vector
Generation of restriction factor-transgenic domestic cats
Eric Poeschla |
| 14:00 |
The frequency of occurence and nature of recombinant FeLVs in the induction of multicentric lymphoma by infection of the domestic cat with FeLV-945
Shamim Ahmad |
| 14:15 |
Enhanced binding of the surface glycoprotein of FeLV-945 from a natural cohort may alter the disease spectrum
Lisa Bolin |
| 14:30 |
Rapid development of lymphomas in cats with virulent FIV infection
Martha MacMillan |
| 14:45 |
FeLV inhibition in vitro by peptides derived from the transmembrane protein
Eva Boenzli |
| 15:00 |
Break |
| 15:30 |
Session III: Intracellular Restriction to Retroviral Infection
Retroviral restriction in the feliformia: A role for TRIM5α?
Brian Willett |
| 15:50 |
Restriction of FeLV in murine and human cells expressing the FeLV-A receptor
Shamim Ahmad |
| 16:10 |
Cat tetherin is a potent retorviral restriction factor
Isabelle Dietrich |
| 16:30 |
The reduction of P27 FELV protein expression in feline cells by interference RNA
Sócrates Ornelas |
| 16:50 |
FIV tissue distribution during co-infection with avirulent lentivirus
Sue VandeWoude |
| 17:30 |
Bus departs Mills House for Middleton Place |
| 18:00 |
Conference Dinner at Middleton Place |
| Tuesday, May 25 |
| 09:00 |
Session IV: Clinical Aspects of FIV/FeLV
Clinical aspects of feline immunodeficiency and FeLV infection
Katrin Hartmann |
| 09:30 |
Seroprevalence of FeLV and FIV infection in Canada
Susan Little |
| 09:45 |
Incidence of progressive and regressive FeLV infection in cats with lymphoma
Bianca Stuetzer |
| 10:00 |
Hematalogical alterations in cats infected with FIV or FeLV
Esperanza Gomez-Lucia |
| 10:15 |
Break |
| 10:45 |
Steroid deregulation in cats infected with FIV and/or FeLV
Esperanza Gomez-Lucia |
| 11:00 |
Effect of a Neruokinin-1 receptor antagonist (aprepitant) on FIV viral load in seropositive cats
Angela Mexas |
| 11:15 |
Comparison of different therapies in cats spontaneously injected with FIV: Zidovudine versus zidovudine associated to valproic acid
Nelida Virginia Gomez |
| 11:30 |
Evolution of the CD4:CD8 ratio and virological parameters in FIV or FeLV infected cats treated with recombinant human interferon-alpha
Esperanza Gomez-Lucia |
| 11:45 |
Lunch and poster viewing |
| 13:15 |
Session V: Vaccines
A customized boost of engineered T-lymphocytes induces high level neutralizing antibody and affords marked protection against FIV
Mauro Pistello |
| 13:45 |
Development of Lactobillus gasseri as a vaccine vector against FIV/HIV
Laura Stoeker |
| 14:05 |
Cross-reactive FIV epitopes in the development of an HIV-1 vaccine for humans
Patrick Sanou |
| 14:25 |
Establishing a model of lentiviral cellular latency in the FIV-C infected cat
Brian Murphy |
| 14:45 |
Break |
| 15:15 |
Session VI: Neuropathogenesis
The entry of immunodificiency-inducing lentiviruses into the central nervous system: Barriers to overcome
Sean Callanan |
| 15:45 |
Novel neuroprotective strategies for FIV
Rick Meeker |
| 16:15 |
Early cognitive decline following intracerebroventricular FIV inoculation
G Clary |
| 16:35 |
Strain-specific neuropathology of FIV
Craig Miller |
| 19:00 |
Steering committee dinner/meeting
Open evening for attendees |
| Wednesday, May 26 |
| 08:30 |
Session VII: Feline Genomics and Application of Genomic Tools
Title TBD
Steve O'Brien |
| 09:00 |
Analysis of virus-host interactions in FIV-infected cells using massive parallel sequencing technology
Dieter Klein |
| 09:20 |
Looking for footprints of viral selection on the feline and canine transferrin receptor sequence
Colin Parrish |
| 09:40 |
Break |
| 10:10 |
Session VIII: Immunopathogenesis: Regulatory T-Cells
Introduction to regulatory T-cells
Dorothee Bienzle |
| 10:25 |
FIV infection induces immune deficiency of CD4+Th and CD8+ T-cells via upregulation of mTGFB on T-reg cells and TGBRII on target T-cells
Michelle Miller
|
| 10:45 |
A unique cell cycle profile in CD8+ lymphocytes from FIV+ cats following CD4+CD25+ T-regulatory cell co-culture may help explain impaired CD8+ responses during AIDS lentiviral infections
Jonathan Fogle |
| 11:05 |
FoxP3 inhibits NFAT2-dependent IL-2 production and causes anergy in CD4+CD25+ T regulatory cells in chronic FIV infection
Liping Meng |
| 11:25 |
Regulatory T-cell depletion prior to FIV infection does not alter acute disease pathogenesis
Rochelle Mikkelsen |
| 11:45 |
Lunch |
| 13:15 |
Session IX: Immunopathogenesis: Innate Immunity
Introduction to innate immunity
Paul Avery |
| 13:30 |
FIV as a model for studies of innate immune cell function during lentiviral infections
Wendy Sprague |
| 13:50 |
In vivo assessment of natural killer cell functional impairment during chronic feline immunodeficiency virus infection
Rita Simoes |
| 14:10 |
Induction of resistance to viral infections in the cat by stimulation of the innate immune system
Celine Robert |
| 14:30 |
Development, optimization and validation of a multiplex microsphere-based feline cytokine assay
Britta Wood |
| 14:50 |
Break |
| 15:20 |
Session X: Non-Domestic Cats and Epidemiology
Genetic determinants of pathogenesis by feline infectious peritonitis virus (FIPV): A study of free-ranging cat isolates
Meredith Brown |
| 15:40 |
Use of host and pathogen molecular markers to determine population substructure among bobcats (Lynx rufus) in a fragmented landscape in southern California
Justin Lee |
| 16:00 |
Detection of feline foamy virus-specific antibodies in domestic and wild cats
Martin Loechelt |
| 16:20 |
Evolutionary dynamics of endogenous feline leukemia virus proliferation among species of the domestic cat lineage
Alfred Roca |
| 16:40 |
Development of a product enhanced reverse transcriptase (pert) assay to determine retorvirus viral load in the plasma of wild African lions
Melody Roelke |
| 19:00 |
Reception at aquarium, young investigator awards and farewell |
Concentration and purification of FIV using tangential flow filtration and ultra centrifugation
Melanie Ammerbach
Investigation of the relationship between cell signalling and the growth and latency of FIV
Chi Ngai Chan
The use of recombinant interferon-omega in naturally FeLV, FIV or co-infected cats: a case report
Esperanza Gomez-Lucia
Evaluation of adrenal and thyroid axes in natural FIV-infected cats, with and without antiviral treatment
Nelida Virginia Gomez